Endoplasmic Reticulum Stress: Implications for Neuropsychiatric Disorders
نویسندگان
چکیده
منابع مشابه
Endoplasmic Reticulum (ER) Stress and Endocrine Disorders
The endoplasmic reticulum (ER) is the organelle where secretory and membrane proteins are synthesized and folded. Unfolded proteins that are retained within the ER can cause ER stress. Eukaryotic cells have a defense system called the "unfolded protein response" (UPR), which protects cells from ER stress. Cells undergo apoptosis when ER stress exceeds the capacity of the UPR, which has been rev...
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Telomerase contributes to cell proliferation and survival through both telomere-dependent and telomere-independent mechanisms. In this report, we discovered that endoplasmic reticulum (ER) stress transiently activates the catalytic components of telomerase (TERT) expression in human cancer cell lines and murine primary neural cells. Importantly, we show that depletion of hTERT sensitizes cells ...
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ژورنال
عنوان ژورنال: Chonnam Medical Journal
سال: 2019
ISSN: 2233-7385,2233-7393
DOI: 10.4068/cmj.2019.55.1.8